Tiamulin Fumarate

Synonyms

* ((2-(DIETHYLAMINO)ETHYL)THIO)ACETIC ACID 8-ESTER WITH (3AS,4R,5S,6S,8R,9R,9AR,10R)-OCTAHYDRO-5,8-DIHYDROXY-4,6,9,

10-TETRAMETHYL-6-VINYL-3A,9-PROPANO-3AH-CYCLOPENTACYCLOOCTEN-1(4H)-ONE FUMARATE;sq22947;

* ter,(e)-2-butenedioate(1:1)(salt);

* thiamutilinfumarate;

* STAMULIN;

* TIAMULIN FUMARATE;

* TIAMULIN FUMERATE;

* TIAMULIN HYDROGEN FUMARATE

Chemical Name

Acetic acid, [[2-(diethylamino)ethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,

10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, (2E)-2-butenedioate

Molecular formula

C32H51NO8S

Molecular weight

609.82

CAS No.

55297-96-6

Structural formula

Specification

Appearance: White to off-white crystalline powder

Assay (HPLC): ≥ 98%

Identification: IR/UV spectrum complies

Loss on Drying: ≤ 1.0%

Residual Solvents: Within ICH limits

Heavy Metals: ≤ 10 ppm

Pharmacodynamic Properties

Mode of Action: 

Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, interfering with peptidyl transferase activity.

Spectrum: 

Effective mainly against Gram-positive bacteria and certain Gram-negative anaerobes.

Particularly active against Mycoplasma spp., Brachyspira hyodysenteriae, Actinobacillus pleuropneumoniae, and some Clostridium spp.

Limited activity against Enterobacteriaceae.

Additional Effects:

Strong efficacy in respiratory and enteric infections of livestock.

Bacteriostatic, but can be bactericidal at higher concentrations against sensitive organisms.

Key Features:

Belongs to the pleuromutilin class of antibiotics.

Widely used in veterinary medicine (pigs and poultry).

Excellent activity against swine dysentery and enzootic pneumonia.

In short: 

Tiamulin fumarate is a veterinary pleuromutilin antibiotic with potent activity against mycoplasmas and anaerobic bacteria, making it a key drug for respiratory and enteric diseases in pigs and poultry.

Storage

Store in a tightly sealed container.

Keep in a cool, dry place (15–25 °C).

Protect from light and moisture.

MSDS

Provide as per request after the order or contract is signed.