Closantel uncouples oxidative phosphorylation in parasite mitochondria, leading to a disruption of ATP production. This results in energy depletion and parasite death.
Product Description
| Synonyms |
* Closantelum [INN-Latin], * Faskoverm, * R 31520 * N-[5-Chloro-4-(4-chloro--cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, * 5'-Chloro-4'-(4-chloro--cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide, * N-(5-Chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide, * Closantel [USAN:BAN:INN], * R 31520, * 5'-Chloro-.alpha.4-(p-chlorophenyl)-.alpha.4-cyano-3,5-diiodo-2', 4'-salicyloxylidide, * 5'-Chloro-alpha(sup 4)-(p-chlorophenyl)-alpha(sup 4)-cyano-3,5-diiodo-2',4'-salicyloxylidide, * Benzamide, N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodo-, * EINECS 260-967-1, * NSC335306, * R 31,520, |
| Chemical Name | N-[5-chloro-4-[(4-chlorophenyl)-cyano-methyl]-2-methyl-phenyl]-2-hydroxy-3,5-diiodo-benzamide |
| Molecular formula | C22H14Cl2I2N2O2 |
| Molecular weight | 663.07 |
| CAS No. | 57808-65-8 |
| Structural formula |  |
| Specification |
Appearance: White to off-white crystalline powder Identification: IR spectrum conforms to reference standard Positive iodine reaction Assay (HPLC): 98.0% – 102.0% (on dried basis) Loss on Drying: ≤ 0.5% Residue on Ignition (Sulphated Ash): ≤ 0.2% Related Substances (HPLC): Any individual impurity: ≤ 0.5% Total impurities: ≤ 1.0% Melting Point: 215 – 220 °C Heavy Metals: ≤ 20 ppm Solubility: Practically insoluble in water; freely soluble in dimethylformamide and dichloromethane; slightly soluble in ethanol |
| Pharmacodynamic Properties |
Mode of Action: Closantel uncouples oxidative phosphorylation in parasite mitochondria, leading to a disruption of ATP production. This results in energy depletion and parasite death. Spectrum of Activity: Effective against adult and immature stages of Fasciola hepatica (liver fluke). Active against certain gastrointestinal nematodes (e.g., Haemonchus contortus). Effective against blood-sucking ectoparasites such as ticks, mites, and lice. Onset & Duration: Provides long-lasting activity due to strong binding to plasma proteins, particularly albumin. |
| Storage | Store in a tightly sealed container. Keep in a cool, dry place away from light. Recommended storage temperature: below 25 °C. |
| MSDS | Provide as per request after the order or contract is signed. |
● Packaging method: 1kg aluminum foil bag, 25kg cardboard or fiber drum, 25kg aluminum tin
● Transportation methods: sea freight, air freight, land freight, international express (DHL, FEDEX, UPS, etc.) are all available
